Professor Sir Magdi Yacoub Publications
Title of Publication: May Measurement Month 2023: results of an opportunistic blood pressure screening campaign in Egypt
Abstract (summarized): This study details the 2023 May Measurement Month (MMM) campaign in Egypt, which screened 2,701 adults to raise awareness about high blood pressure. The findings revealed that 24.5% of participants had hypertension, with significant gaps in awareness and control, particularly among males. The study underscores the urgent need for community-centric screening, public education, and clinical management to reduce cardiovascular risk and address the high burden of inadequately treated hypertension.
Journal: European Heart Journal Supplements
Date of Publication: 03 August 2026
Title of Publication: Transcriptomic signature of Human Cardiac Fibroblast in Hypertrophic Obstructive Cardiomyopathy
Abstract (summarized): This research investigated the transcriptome signature of cardiac fibroblasts (CFs) in patients with Hypertrophic Obstructive Cardiomyopathy (HOCM). By isolating primary CFs from myectomy specimens and conducting whole transcriptome sequencing, the study identified 265 differentially expressed genes primarily related to extracellular matrix (ECM) organization and inflammatory responses. The findings demonstrate that advanced HOCM-CFs acquire a specific inflammatory-remodeling phenotype driven by complex cell-matrix communication.
Journal: bioRxiv (Preprint)
Date of Publication: 17 July 2026
Title of Publication: Matrisome remodeling in the myocardium of hypertrophic cardiomyopathy; novel targets for molecular diagnostics
Abstract (summarized): This comprehensive review dissects the composition of the myocardial extracellular matrix (ECM) in relation to Hypertrophic Cardiomyopathy (HCM) pathogenesis. It highlights how the crosstalk between cardiomyocytes, cardiac fibroblasts, immune cells, and the microvasculature regulates the secretion of inflammatory mediators and ECM proteins. The paper identifies key cellular contributions to this remodeling process and proposes potential molecular targets for personalized diagnostics and therapeutics.
Journal: Frontiers in Cell and Developmental Biology
Impact Factor / Quartile: Impact Factor 5.3 (CiteScore 9.9)
Date of Publication: 06 August 2025
Title of Publication: Structural and Functional Characterization of the Aorta in Hypertrophic Obstructive Cardiomyopathy
Abstract (summarized): This study examined the structural and functional alterations in the ascending aorta of 101 patients with obstructive HCM. Histological and molecular analyses revealed a significant decrease in medial lamellar units, disorientation of elastin fibers, and reduced expression of structural proteins like integrin β1 and fibulins. Functionally, these patients exhibited higher aortic pulse wave velocity compared to controls, indicating increased wall stiffness and highlighting potential arterial dysfunction associated with the disease.
Journal: AHA journals, Circulation: Heart Failure
Date of Publication: 23 January 2025